There seems to be a “crisis” of lack of clinical studies or collection of specific data points to establish a SOLID RELATIONSHIP BETWEEN OPIOIDS BEING REDUCED and various blood pressure complications and/or cardiovascular adverse events.  MAYBE there is a relationship, but no one has intentionally bothered to collect the data

Asking perplexity.ai involuntary reduction of opioid pain meds causing hypertensive crisis blood pressure level

The search results do not provide specific clinical studies or percentages directly addressing hypertensive crisis levels (200/100+) in chronic pain patients after involuntary opioid reduction. However, some relevant information can be extracted:

1. Opioid tapering has been associated with increased rates of adverse events, including:
– Higher rates of overdose and mental health crises up to 2 years after taper initiation[4].
– Increased emergency department visits and hospitalizations[9].

2. There is a complex relationship between pain, blood pressure, and opioid use:
– Acute pain typically causes an increase in blood pressure[5].
– Chronic pain may lead to persistent elevation in blood pressure over time[5].
– Opioid withdrawal can trigger major adverse cardiovascular events[7].

3. A study found small but statistically significant increases in diastolic blood pressure among patients who underwent opioid tapering[9].

4. Rapid opioid dose reductions (>30% per month) were associated with a fivefold increased risk of overdose in the first month after initiating a taper[1].

While these findings suggest that involuntary opioid reduction can impact cardiovascular health and potentially increase blood pressure, the available data does not provide specific information on hypertensive crisis levels or the percentage of chronic pain patients experiencing such severe elevations in blood pressure after involuntary opioid reduction.

Citations:
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9509303/
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC6957663/
[3] https://med.umn.edu/news/u-m-medical-school-researchers-find-blood-pressure-medications-impact-brain-function
[4] https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2793293
[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC8033897/
[6] https://www.pbm.va.gov/PBM/AcademicDetailingService/Documents/Pain_Opioid_Taper_Tool_IB_10_939_P96820.pdf
[7] https://www.jacc.org/doi/10.1016/j.jacc.2020.11.002
[8] https://www.fda.gov/drugs/drug-safety-and-availability/fda-identifies-harm-reported-sudden-discontinuation-opioid-pain-medicines-and-requires-label-changes
[9] https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801014

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