New type of opioid targets pain areas directly avoiding negative side effects
https://medicalxpress.com/news/2017-03-opioid-pain-areas-negative-side.html
(Medical Xpress)—A team of researchers with the Free University of Berlin and Zuse-Institut Berlin has developed a type of opioid that was shown to target pain in rats without causing negative side effects. In their paper published in the journal Science, the team describes the new opioid, how well it worked in rats and the side effects that were eliminated.
As part of their research, the group noted that the parts of the body that hurt typically result in inflammation as the body tries to repair itself. They further noted that body parts experiencing inflammation tend to be more acidic than other parts. Because of that, they set about developing an opioid that would bind only to nerve receptors that exist in acidic environments. Opioids binding to untargeted parts of the body are what cause side effects, after all—binding to nerve cells in the gastrointestinal tract, for example, causes constipation and binding to nerve cells in the brain is what leads to feelings of euphoria and addiction.
The researchers tested the new opioid on rats, and found that it was comparable to the commonly prescribed opioid fentanyl in relieving pain, but it did not cause constipation, addiction, breathing problems, heart rate increases or changes to blood oxygen levels. In short, it appeared the new opioid alleviated pain as well as current opioids, but did not cause any noticeable side effects.
More research is required to test both the efficacy and safety of the opioid in rats and other test animals before it can be tested in humans, but if the opioid turns out to work in humans the way it does in rats, it could mark a truly transformative moment in medical science—a true breakthrough in pain mitigation and management.
Filed under: General Problems
The biggest problem is the government narrative. Pain patients are a burden to society.
Dear Kim,
I’m not sure that the “new” opioid treatment is what Candace had in mind, and, I am discussing the UNTOLD & TOXIC EFFECTS FROM NON-STANDARDIZED, MIS-REPRESENTED, AND FRAUDULENT COUNTERFEIT OXYCODONE & ADDERALL, DEXTROAMPHETAMIME SULPHATES.
LOOK UP “CANDACE PERT,Phd…”
THE “REAL” DISCOVERER OF “the opiate receptor” at NIH…, & SO MUCH MORE THAN I CAN LIST HERE: (Including:” Peptide T”, subject of the movie starring Matthew McConaughey, “Dallas Buyers Club”), friend of Deepak Chopra….
The woman who is the true hero, and never got the credit due her! (She died in 2013, just before launching “Rapid Pharmaceuticals…”) please look her up!!!
CANDACE PERT,PHD.
Thank you Candace Pert, for all your compassion, courage, activism…
Please give this credit where it is OVERDUE… TO CANDACE PERT, Phd.,who worked tirelessly for most of her life for the NIH (& wasn’t afraid to tell the truth of such establishments…), to find the “opiate receptor”, who also discovered “Peptide T” (relating to HIV treatments, and about which a movie was made “Dallas Buyers Club”, starring Matthew McConaughey…) Published mind/body medicine books/articles… Cherished her friendship with Deepak Chopra… LOOK HER UP!!!!
She also was an activist/courageous woman/ who ironically died just before launching her own pharmaceutical company, “Rapid Pharmaceuticals” 2013…. I can only hope this email message will reach so many who have no idea of the extent of her contribution to our collective well being/healing! Love you Candace Pert! So Grateful for you!!! Truth Rules!!
I am unable to finnish reading this post as I know [a], if it’s not broke, don’t fix-it, and the “oxycodone”, ADHD-“amphetamines” were/are-already compromised since the “shortages”.
[b], What doesn’t make the news-is that the basic human and constitutional “rights” of the most vulnerable of us were/are sold-out, forfeited, from the Obama Administration-primarily.
[c], I strongly encourage all people with chronic-illness, and on “pain-meds” to receive a HEAVY METAL BLOOD TEST, as mine revealed dangerous levels of CADMIUM, TRIOXIDE, CEPHALON. CADMIUM HEAVY-METAL POISONING IS A PAIN DIAGNOSES IN ITSELF. GOOGLE-IN : JAPAN, CADMIUM POISONING EFFECTS, [what comes-up is PAIN PAIN PAIN-IN JAPANESE.
[d], I must be different from the pain advocates that I read about because, I don’t have the patience, “neutrality”, subservience, to just-about sell-out the intense-holocaustic EMERGENCY THAT UNTREATED PAIN REQUIRES.
My doctor told me that there were a couple in the pipeline. Thank God! Those of us with multi-drug sensitivities and that live where medical marijuana isn’t approved would love an alternative. If you are a traumatic brain injury survivor and can’t process long chain opiods, we’re even more limited. The DEA and. FDA are beating up our doctors who treat those who legitimately need them and scare the public with falsehoods.