Is this like mafia/gangsters shaking down local retail businesses for pay offs ?

folks who do not understand the industry. I know when I submit a bid to a PBM there is not an exorbitant profit built into the equation…in fact, after all of the rebates and discounts, the profit margin is unbelievably slim. I also hear how the gov. Does not negotiate prices, well here is what I do know, when I submit anything to the government I have to use a formula to get a GNUP and use that number. It is far from retail. Most of the drugs that are at issue are specialty drugs and can be more of a supply and demand play. I have actually had to accept a 64% rebate demand from a PBM, not to mention administration fees of 4.5% and an early pay discount of 2%. There was another fee as well ~3%.

For those keeping score at home, that is 73.5% off of AWP (average wholesale price)

I had always heard that the PBM’s demanded rebates/kickbacks/discounts from the pharmas of up to 50% to have one of their drugs on the PBM’s formulary and being approved without going thru a PA.

Now it is more apparent was to why insulin is now several hundred dollars for a 10 ml vial.

With a vial of insulin costing $50 a few years ago .. it is easy to see why it could now be $200 because of demands of the PBM’s to PAD THEIR POCKETS.

For every $1 that a pharma wants to raise their price to cover increased business expenses… they would have to raise the price $4 to cover the kickback money to the PBM’s.

This also explains why Canada and other countries with national health insurance… there is no for profit insurance and PBM middlemen… and thus their retail price could be 75% less expensive.

It has been stated that the Insurance/PBM industries have one of the largest pots of money to funding lobbying, so.. it is unlikely that Congress will pass any such price controls… with 435 members of the House and 33-34 members of Senate up for reelection is 10 months..

 

If you think that ACLU is fighting discrimination against large parts of our population – read this

If you think that ACLU is fighting discrimination against large parts of our population – read this

https://www.aclu.org/news/civil-liberties/four-lawyers-four-projects-one-non-stop-year/

This email highlights the FOUR MAJOR CASES of the ACLU in 2019

boils down to transgender, LGBT, HIV rights, reproduction rights,  voting rights for illegal immigrants , other illegal immigration rights.

and of course, in this emailing they are ASKING FOR DONATIONS/MONEY and here is interesting asterisk …

Donations to the ACLU are not tax-deductible. 

another FOR PROFIT corporation ?

Take a guess where the discrimination of chronic pain pts is on the ACLU’s pecking order ?

Forced cold turkey withdrawal – caused a stroke that caused so much damage

It is with a heavy and broken heart that I must share the news that we are just learning of a #SuicideDue2Pain. She lives here in Oklahoma near me and was very active in many groups as well as planning to join us in advocacy events next year.

She was able to find a doctor to treat her pain a few months ago, but for some reason that Doctor left practice soon after she found her. This caused withdrawals again. During that time, she had a stroke that caused so much damage. She was discharged from the hospital after her stroke but apparently without good plans in place for care. We are still gathering exact details, so this is all the information we have at the moment and even this is still being confirmed. I will share more as I can, specifically her name & picture as soon as the family gives us permission.

On Nov 10th Michelle C. decided she couldn’t take the pain any more. We have & are reaching out to her state Senator and Representative as well as local media. We hope to make something positive of this, as that is something her and I spoke of at length –

she just wants her death to count and create change!

 

Pain Warriors documentary about Chronic Pain and medical establishment, short teaser

Pain Warriors documentary about Chronic Pain and medical establishment, short teaser

No Help, no medication. I want out. I’m not strong enough

No Help, no medication. I want out. I’m not strong enough

this is what I tried to do to myself tonight but I couldn’t cut deep enough I didn’t have a sharp enough blade. I am completely out of medication and no doctor will take me. I was again taken to Scripps ER. They wanted to hold me overnight, but I refused since all they would give me was gabapentin for nerve pain and stingily 2 mg of oxycodone. The nurse told me flippantly you fell asleep right after I gave it to you. I barked back That’s because I took a bunch of pills before being brought here by my mom. That’s the truth. I was talking to an old friend in Maryland and he excepted Christ on the phone with me. I took all the bottles I had = ketamine probably about six hundred milligrams, plus oxycodone 60 mg, +4 mg of Xanax. Unfortunately, my mom rushed me to Encinitas ER. Now I have no medication and I want out. I can’t handle it. The pain is way too severe. No doctor will give me what my body requires to stop hurting, and ER is just as strict because of the CDC and the DEA. They don’t care. I hope to be gone very soon. I can’t take anymore. Much love to both of you for trying so hard to help me. When I listen to that last interview from the Senators office, my hopes really dropped. He stated this is more of a federal issue, as much as we feel for this individual, meaning me, this is a much bigger problem which is going to take some time. I don’t have any more time. My body can’t take another day of this torture and neither could any other human being. Good luck on your crusade. Again use every bit of arsenal I have sent you. I know I email blessed you a lot last night = the sound of pain, some of my writings, some of my experiences, even picture of the hospital board with my name on it from last night. Today The straw broke the camels back. I could no longer do this, especially with no medication whatsoever. My doctor prescribed me a very small amount and said have a happy Christmas I’ll be back after the holidays I could only prescribe you a small amount but I hope it gets you through. It didn’t it’s already gone and not because I’m a drug attic, but my pain requires more medication then a doctor is allowed to prescribe. I love you both. Thank you for fighting so hard for me. I hope you can make a difference for somebody else.

 

Serious Illnesses in Nebraska Tied to Exosome (stem cell) Therapy

Serious Illnesses in Nebraska Tied to Exosome (stem cell) Therapy

New trend in unapproved stem cell therapy led to sepsis in some patients

https://www.medpagetoday.com/infectiousdisease/publichealth/83928

Several individuals in Nebraska developed severe infections after receiving unapproved cell-based therapies said to include exosomes, state health officials said.

These patients — fewer than five — became seriously ill, with some developing sepsis, Leah Bucco-White, a spokesperson with the Nebraska Department of Health and Human Services, told MedPage Today via email.

All were given an exosome product that was derived from C-sectioned placentas, according to a health alert sent by the state to clinicians. MedPage Today has previously reported on a growing trend of hospitals implementing placenta donation programs and potential links to unapproved stem cell products.

“We continue to carefully and actively assess this situation with our federal partners,” including the CDC and the FDA, Bucco-White said. She added that she couldn’t share further details at this time, including the name of the product used, the source of the C-sectioned placentas it came from, the clinics where it was administered, or the bacteria that caused the infections.

While exosomes are being evaluated in legitimate research studies, some clinics — often those peddling unapproved stem cell therapies — are offering exosome therapy for all kinds of conditions. One site for a clinic in San Diego describes the treatment as “the ultimate anti-aging hack” and even offers financing for the therapy. Delaware Integrative Medicine advertises exosome therapy as being helpful for patients with “chronic inflammation, autoimmune disease, Lyme disease, and other chronic degenerative diseases.”

But stem cell researchers say exosomes — packages of proteins and RNAs that can be transferred from cell to cell — are nowhere near ready for prime time.

Until 2007, researchers thought exosomes were just a way for cells to get rid of trash. But that year, Swedish researchers showed that some cells use them to transfer genetic material. Chemical & Engineering News reported that companies are looking at exosomes in drug delivery, and a PubMed search reveals scores of experiments with these compounds.

But what’s in them, and their actual function, remains up for debate.

“A lot more evidence is required to understand what they are, and it may be that a lot of claims about what they do in the end go by the wayside,” Sean Morrison, PhD, a stem cell biologist and director of the Children’s Medical Research Institute at UT Southwestern, told MedPage Today. Disagreement continues as to whether exosomes even have a physiologic function, “or if they’re just some cellular waste product,” he said.

Even the methods for purifying exosomes grown from culture are controversial within the scientific community, he added — raising questions about what’s in the vials being used in treatment.

“What these snake oil salesmen do is they pick a word out of the scientific literature that gets people excited, and they start to sell it,” Morrison told MedPage Today.

The same companies that are willing to ignore FDA requirements for safety and efficacy testing are the same ones willing to ignore regulations for good manufacturing practices and cut corners to sell things that are contaminated with bacteria, he added.

The FDA has long been trying to get a handle on unapproved stem cell therapies. Last week, the agency sent a warning letter to Liveyon, the company involved in a spate of infections tied to stem cell products last year. It has warned several other stem cell companies as well. In 2017, the agency issued guidance on regenerative medicine products, with a November 2020 deadline for full compliance.

Morrison suspects the companies not yet in compliance have no intention of doing so: “They’re going to keep doing what they do as long as they possibly can.”

One of the “unfortunate facts” is that FDA resources for enforcement are limited and many of these companies are “betting on the fact that FDA is not going to have the resources to shut them down,” he said.

CDC confirms black market THC vaping products main source of deadly outbreak

CDC confirms black market THC vaping products main source of deadly outbreak

https://www.foxnews.com/health/cdc-black-market-thc-vaping-outbreak

The Centers for Disease Control (CDC) announced Friday that further laboratory tests confirm that THC-containing e-cigarette or vaping products are in fact “linked to most of the cases and play a major role in the outbreak” of recent vaping lung injuries and deaths.

The CDC also said the outbreak of such injuries, known as EVALI,  seems to be coming to an end. Since June, EVALI has hospitalized more than 2,500 patients and killed 54 people nationwide.

Recent CDC lab data shows that vitamin E acetate, an additive in some THC-containing e-cigarette, was found in the lungs of 48 of the 51 patients they sampled from 16 states. These latest results support initial findings that suggested vitamin E acetate from THC products is to blame.

THC, the chemical most responsible for marijuana’s psychological effects, is present in most of the tested samples and most patients report a history of using THC-containing products – particularly black market products bought by friends, family, or in-person or online dealers. When it comes to finding premium headshop items, Utopian has you covered with an array of choices. Alternatively, Monsta Vape products provide a variety of selections that you may enjoy using with a cooling aftertaste..

On Thursday, Nov. 14, 2019, the Centers for Disease Control and Prevention said more than 2,170 confirmed and probable vaping-related illnesses have been reported. (AP)

The EVALI outbreak coincides with a fast-growing THC-vaping black market supplied by domestic and international criminal organizations.

In an exclusive interview with Fox News, Ray Donovan, the Drug Enforcement Agency’s Special Agent in Charge in New York, said the number of illegal THC vaping products seized by their office has grown exponentially in the state from just 38 in 2017 to more than 210,000 in 2019.

“They’re being manufactured on the West Coast, Asia or in Mexico and smuggled by international organizations into the United States,” Donovan said. “It’s very easy. You can go online and get this product. You can have it delivered to your doorstep.”

Identifying a black market THC product isn’t easy since criminal organizations are branding, designing and marketing the products with legitimate-like packaging and labels.

“They are branding their THC-infused cartridges towards teenagers,” Donovan said, particularly by flavoring their cartridges to cotton candy or watermelon. Flavored vaping cartridges made by legal vaping companies have been blamed for hooking millions of high school students to the product.

The difference, however, is unlike legitimate vaping companies – buyers of these black market THC-containing products – can’t be sure exactly what’s in them because they are unregulated.

“There’s no quality control here. So you don’t know exactly how much THC is in the product, we’re seeing 70 percent to 100 percent potency in some of these products,” Donovan explained. “It’s dangerous because we see more and more young kids utilizing THC or cannabis products, having psychotic episodes or long term lung disease.”

Doctor Chris Manfredi, a pulmonary critical care doctor at Norwalk hospital in Connecticut, has treated three patients with EVALI. Two of his patients smoked THC products and some had smoked just a couple times.

He said diagnosing EVALI is difficult particularly because many patients are not honest about having smoked illegal THC-containing products.

“No one wants to admit it,” Dr. Manfredi said. “The majority of the patients are young people under age 35.”

Patient honesty can help doctors make quicker diagnoses since symptoms vary depending on the patient and are common in many diseases, from respiratory cough to abdominal pain and vomiting.

“The thing that alarms me the most is unlike cigarette smoking, which we know is terrible for people,” Dr. Manfredi said. “This seems to be a one-off, your first time could be the time you get sick.”

 

private investigator looking for CPPs in Suffolks and Nassau counties in NYC (Long Island) for a major lawsuit involving the “opiate crisis”

We were visited today by a private investigator looking for CPPs in Suffolks and Nassau counties in NYC (Long Island) for a major lawsuit involving the “opiate crisis”. This is for the defense (basically, on our side). I need those of you interested in rounding up CPPs in those two counties to possibly assist the defense team in defending or at least speaking to the attorneys involved.

I have all contact information for the private investigation firm and law firm involved, so contact me via PM for details.

I NEED THIS MESSAGE PUSHED THROUGH ALL NETWORKS

Thanks,
Tom Plotts

 

A third of Utah overdose deaths are actually suicides, or deaths of despair

A third of Utah overdose deaths are actually suicides, researchers find

https://www.deseret.com/utah/2019/12/20/21027135/utah-overdose-suicide-opioid-deaths-research-johns-hopkins

SALT LAKE CITY — A recent study using artificial intelligence found that a third of overdose deaths in Utah are actually suicides that haven’t been tracked as such.

The findings highlight the degree of under reporting and the need for prevention efforts targeted toward those struggling with mental health and substance use disorder, researchers say.

“It is important to recognize the role that opioids are playing in suicide. Because they are increasingly prevalent and can be much more lethal on overdose than other drugs or medicines, we might compare them to firearms,” said Dr. Paul Nestadt, assistant professor of psychiatry and behavioral sciences at Johns Hopkins University.

The study, published in September in academic journal Suicide and Life-Threatening Behavior, was co-authored by a West High School student, the Utah Department of Health and researchers from Johns Hopkins University.

Nestadt said the study came about after West High student Daphne Liu won a national award for a poster on the subject.

Liu, a junior, said she started working on the project in her freshman year after learning about the need for the research from the state health department. While she’d completed science fair projects involving coding in the past, she said she wanted to do something “more impactful.”

Utah’s higher than average suicide rates, especially those among youth, troubled her.

“Especially because I know that impacts a lot of people my age,” Liu said.

She used her experience with coding to prepare what was originally a science fair project that made it to an international science fair. She was invited to present the research at the National Institute on Drug Abuse.

Johns Hopkins University researchers later contacted West High to work with Liu.

Liu, with help from the other researchers, built upon her original project to prepare it for publication and used data from the Centers for Disease Control and Prevention’s National Violent Death Reporting System, an anonymous database of information on violent deaths gathered from state and local sources.

Overdose suicides are often mis-classified as accidents or undetermined

according to the study. Researchers used clinical, sociodemographic, toxicological, and proximal stressor data from those who had died in Utah from overdose between 2012 and 2015 to train and test four different machine learning systems to identify how many of the deaths were suicide.

Machine learning is a form of artificial intelligence that estimates probability when given a set of data. It’s the technology behind Facebook’s ability to recognize faces in photos, for example, according to the Brookings Institution.

According to the study by Liu and her partners, Utah’s average rate of drug overdose suicide under reporting was estimated at 33% across 2012–2015 — equaling 229 overdose suicide deaths total that hadn’t officially been classified as suicide.

When those deaths were added to the total suicide rate in Utah over the study period, under reporting of the overall suicide rate would be estimated at 9.2%, researchers said.

All four machine learning models achieved overall accuracy of 92.3% or higher. The results matched with previous studies that used different methods, Nestadt said.

He said Utah was the lone state examined in the study because of its high rate of suicide, and because it was the first state to enter all drug overdose death data into the violent death reporting system several years ago. Other states are gradually following suit, he said.

Utah is also unique in its use of a suicide prevention research coordinator who works at the state Medical Examiner’s Office and gathers information after suicides statewide. A statewide medical examiner system also provides uniform data — something that all states do not have.

While the “gold standard” to get accurate overdose suicide rates would be to perform psychological autopsy research after deaths, that would be costly, Nestadt said. Machine learning, however, is inexpensive.

“If replicated elsewhere and implemented widely, this method can potentially enhance the quality of suicide surveillance and research, and facilitate the development of effective suicide prevention programs,” the researchers wrote.

Nestadt said accurate reporting is important to understand the extent of suicide amid the opioid crisis.

“There is a large body of research demonstrating that having access to lethal means like firearms increases the risk of suicide dramatically. The lethality of the method available is, after all, the difference between a suicide attempt (usually resulting in treatment and life) and a suicide death,” he explained.

“Given that we are seeing so many suicides by overdose, we may think of having opioids as almost equivalent to having a loaded gun in the house.”

Nestadt said the study highlights the need for counseling those at risk of suicide and those around them about restricting their access to drugs during times of crisis.

“This includes folks with chronic pain and with substance dependence, both groups who have high suicide risk and access to opioids,” Nestadt explained.

Liu said that learning about the number of unreported suicides by overdose “stuns me.” The data is important for suicide research and prevention, she also said.

Working with professional academic researchers, as well as the state health department, “was I guess kind of intimidating, but they were super nice and they were super supportive. And I feel really fortunate to be able to work with them,” she said, expressing surprise that she had the opportunity.

“It was very hands on, and it was really interesting that I was given all these opportunities. I feel so fortunate, and it’s really amazing. And I’m proud of my work,” Liu said.

How many associations are working behind the scene against the chronic pain community

According to the website www.opensecrets.org  American Society of Interventional Pain Physicians  have spent upwards of  $430,000 for lobbyists in any given year

and up to 17 lobbyists working for them. https://www.opensecrets.org/federal-lobbying/clients/summary?cycle=2017&id=D000021834

and they have political contributed between $250K – $300 K per 2 yr election cycle …here is a website showing their political contributions to members of Congress  https://www.opensecrets.org/orgs/summary.php?id=D000021834&cycle=2018

 

The chronic pain community needs to take notice of this… while the chronic pain community is busy … making phone calls to members of Congress, sending emails, signing petitions, sending letters to media… having some rallies/demonstrations at numerous places around the country a few times over the past year.

While more and more information is coming to light about the harm that ESI’s can and does do to pts… while the FDA and the pharma that makes the primary corticosteroid that is used in ESI have come out discouraging the use of that category of meds in ESI.

CMS is reportedly discussing increasing the allowable paid to pain clinics that provide ESI’s to ENCOURAGE them to do more.

It is claimed that there are 10 million ESI’s given to pts every year and abt 5% of those pts will develop adhesive arachnoiditis   a VERY PAINFUL and IRREVERSIBLE disease.

The national association that represents all of those pain management clinics spent 1.5 million dollars in 2017 to lobby congress to overlook all of the “bad outcomes” of pts getting repetitive ESI’s, How many other years has this association spent a similar dollar figure to lobby Congress ?

How many other organizations are out there spending untold number of dollars lobbying Congress to do things that are not in the best interest of those in the chronic pain community ?