PHARMACIST STEVE

So much COMMON SENSE…. explained in a 15 minute seminar

3 Responses

1. 

   barb, on June 11, 2017 at 7:35 pm said:

   Please let everyone hear and be effected by this brilliant man

   Reply
2. 

   lawhern, on June 11, 2017 at 9:26 am said:

   I have entered the following comment as the first received by U-Tube on Dr Kertesz’ clip:

   I am pleased to see Dr Kertesz speak to the issues in this presentation. The one area which I believe he fails to address is the absolute impossibility of setting a one-size fits all opioid dose limit for chronic pain. There is ample medical evidence that such a dose limit will kill some patients by ignoring hyper-metabolizers of opioids, and under-medicate millions of others who are poor metabolizers of opioids. The mechanism in these dosing problems is well established from medical literature:

   See Tom Lynch, PharmD and Amy Price MD, “The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Events”, American Family Physician, August 1, 2007. http://www.aafp.org/afp/2007/0801/p391.html

   “Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a patient’s response to commonly prescribed drug classes, including beta blockers and antidepressants. Cytochrome P450 enzymes can be inhibited or induced by drugs, resulting in clinically significant drug-drug interactions that may cause unanticipated adverse reactions or therapeutic failures…”

   I too have written about this important issue of public policy. See “Warning to the FDA – Beware of Simple Solutions in Chronic Pain and Addiction”, National Pain Report, June 1, 2017.

   Reply
3. 

   maryw, on June 10, 2017 at 10:46 pm said:

   hmmm who is this guy and we need him on ,”our” side,,,maryw

   Reply